| | |  | | | | Record from Web of Science® | | | | | | |
| Impaired wound healing in mice with a disrupted plasminogen gene |
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| Author(s): Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K |
| Source: NATURE MEDICINE Volume: 2 Issue: 3 Pages: 287-292 Published: MAR 1996 |
| Times Cited: 333 References: 40 |
| Abstract: Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in plg by targeted gene disruption. The results demonstrate that plg is required for normal repair of skin wounds in mice and support the assumption that it also plays a central role in other disease processes involving extracellular matrix degradation, such as cancer invasion. |
| Document Type: Article |
| Language: English |
| Reprint Address: Romer, J (reprint author), RIGSHOSP, FINSEN LAB, STRANDBOULEVARDEN 49, DK-2100 COPENHAGEN O, DENMARK |
Addresses:
1. CHILDRENS HOSP RES FDN, DIV DEV BIOL, CINCINNATI, OH 45229 USA
2. UNIV CALIF SAN FRANCISCO, RADIOBIOL & ENVIRONM HLTH LAB, SAN FRANCISCO, CA 94143 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: TY640 |
| ISSN: 1078-8956 |
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