| | |  | | | | Record from Web of Science® | | | | | | |
| Taxol induces bcl-2 phosphorylation and death of prostate cancer cells |
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| Author(s): Haldar S, Chintapalli J, Croce CM |
| Source: CANCER RESEARCH Volume: 56 Issue: 6 Pages: 1253-1255 Published: MAR 15 1996 |
| Times Cited: 513 References: 20 |
| Abstract: Treatment of prostate cancer cell lines expressing bcl-2 with taxol induces bcl-2 phosphorylation and programmed cell death, whereas treatment of bcl-2-negative prostate cancer cells with taxol does not induce apoptosis. bcl-2 phosphorylation seems to inhibit its binding to bar since less bar was observed in immunocomplex with bcl-2 in taxol-treated cancer cells. These findings support the use of the anticancer drug taxol for the treatment of bcl-2-positive prostate cancers and other bcl-2-positive malignancies, such as follicular lymphoma. |
| Document Type: Article |
| Language: English |
| Reprint Address: Haldar, S (reprint author), THOMAS JEFFERSON UNIV, JEFFERSON MED COLL, JEFFERSON CANC INST, 233 S 10TH ST, BLSB, ROOM 1032, PHILADELPHIA, PA 19107 USA |
Addresses:
1. THOMAS JEFFERSON UNIV, JEFFERSON MED COLL, JEFFERSON CANC CTR, PHILADELPHIA, PA 19107 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: TZ527 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |