| | |  | | | | Record from Web of Science® | | | | | | |
| Does graft-versus-host disease attack epithelial stem cells? |
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| Author(s): Sale GE |
| Source: MOLECULAR MEDICINE TODAY Volume: 2 Issue: 3 Pages: 114-119 Published: MAR 1996 |
| Times Cited: 13 References: 32 |
| Abstract: Graft-versus-host disease (GvHD) is the opposite of graft rejection in that a transplant containing donor lymphocytes attacks the host's skin, liver and gut, This disease can usefully also attack host tumor cells, There is a peculiar distribution of normal tissue targets in epithelial stem cell sites, suggesting that GVHD may be the abnormal counterpart of a physiological growth control system, Efforts to understand how the graft-versus-tumor effect could be therapeutically separated from GvHD require further understanding of the mechanisms involved in GvHD. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sale, GE (reprint author), FRED HUTCHINSON CANC RES CTR, DEPT PATHOL, CLIN DIV, 1124 COLUMBIA ST, ROOM SC-11, SEATTLE, WA 98104 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: TZ849 |
| ISSN: 1357-4310 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |