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| A comprehensive genetic map of the human genome based on 5,264 microsatellites |
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| Author(s): Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J |
| Source: NATURE Volume: 380 Issue: 6570 Pages: 152-154 Published: MAR 14 1996 |
| Times Cited: 2,460 References: 21 |
| Abstract: The great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps(1-6), which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites(7,8). We report here the last version of the Genethon human linkage map(6). This map consists of 5,264 short tandem (AC/TG)(n) repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM. |
| Document Type: Article |
| Language: English |
Addresses:
1. GENETHON SA, F-91000 EVRY, FRANCE
2. CNRS, URA 1922, F-91000 EVRY, FRANCE
3. HOP ST LOUIS, INSERM, U358, PARIS, FRANCE
4. CHU LAVAL, CTR RECH, QUEBEC CITY, PQ G1V 4G2 CANADA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: TZ978 |
| ISSN: 0028-0836 |
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