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| Induction of T(H)1 and T(H)2 immunity in neonatal mice |
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| Author(s): Forsthuber T, Yip HC, Lehmann PV |
| Source: SCIENCE Volume: 271 Issue: 5256 Pages: 1728-1730 Published: MAR 22 1996 |
| Times Cited: 457 References: 35 |
| Abstract: The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (T(H)2) immune response. Thus, neonatal ''tolerization'' induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate T(H)2 or T(H)1 responses, depending on the mode of immunization. |
| Document Type: Article |
| Language: English |
Addresses:
1. CASE WESTERN RESERVE UNIV, DEPT PATHOL, CLEVELAND, OH 44106 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UB151 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |