| | |  | | | | Record from Web of Science® | | | | | | |
| Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man |
|
|
| Author(s): Assenmacher M, Scheffold A, Schmitz J, Checa JAS, Miltenyi S, Radbruch A |
| Source: EUROPEAN JOURNAL OF IMMUNOLOGY Volume: 26 Issue: 1 Pages: 263-267 Published: JAN 1996 |
| Times Cited: 47 References: 36 |
| Abstract: Interferon (IFN)-gamma is a potent immunoregulatory protein secreted by CD4(+) and CD8(-) T cells and by natural killer cells. Here, we show that IFN-gamma is specifically displayed at a low concentration on the cell surface of those activated T cells from mouse and man which express IFN-gamma. It is transiently expressed on the cell surface with kinetics similar to those of intracellular IFN-gamma expression. Detectable surface IFN-gamma is not expressed by activated T helper (Th) cells producing other cytokines but which do not express IFN-gamma. Thus, surface IFN-gamma is the first available marker for live T lymphocytes expressing IFN-gamma, e.g. Th1 cells. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV COLOGNE, INST GENET, D-50931 COLOGNE, GERMANY
2. UNIV COLOGNE, ZENTRUM MOL MED, D-50931 COLOGNE, GERMANY
3. MILTENYI BIOTEC GMBH, BERGISCH GLADBACH, GERMANY |
| Publisher: VCH PUBLISHERS INC, 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 |
| Subject Category: Immunology |
| IDS Number: UD138 |
| ISSN: 0014-2980 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |