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| Cloning of P2X(5) and P2X(6) receptors and the distribution and properties of an extended family of ATP-gated ion channels |
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| Author(s): Collo G, North RA, Kawashima E, MerloPich E, Neidhart S, Surprenant A, Buell G |
| Source: JOURNAL OF NEUROSCIENCE Volume: 16 Issue: 8 Pages: 2495-2507 Published: APR 15 1996 |
| Times Cited: 652 References: 35 |
| Abstract: Two new P2X receptor cDNAs (P2X(5) and P2X(6)) were isolated and expressed. All six proteins are 36-48% identical and seem to have two transmembrane segments with a large extracellular loop. Functionally, P2X(5) and P2X(6) receptors most resemble P2X(2) and P2X(4); they desensitize only slowly and do not respond to alpha beta methylene-ATP. P2X(6) receptors, like P2X(4) receptors, are not blocked by the antagonists suramin and pyridoxal-5-phosphate-6-azophenyl-2',4'-disulfonic acid. P2X(6) and P2X(5) receptors express at lower levels than P2X(1)-P2X(4) receptors do, perhaps indicating that they do not normally form homomultimeric channels. P2X(6) and P2X(4) are the receptors expressed most heavily in brain, where their RNAs have a widespread and extensively overlapping distribution. The spinal cord expresses all receptors except P2X(3). P2X(2), P2X(4), and P2X(6) are the most abundant in the dorsal horn. Sensory neurons of the trigeminal, dorsal root, and nodose ganglia express all six RNAs; P2X(3) is found only there. The functional properties and tissue distribution of these six P2X receptors indicate new roles for ATP-gated ion channels. |
| Document Type: Article |
| Language: English |
Addresses:
1. GLAXO INST MOLEC BIOL SA, CH-1228 GENEVA, SWITZERLAND |
| Publisher: OXFORD UNIV PRESS INC, JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 |
| Subject Category: Neurosciences |
| IDS Number: UD671 |
| ISSN: 0270-6474 |
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