| | |  | | | | Record from Web of Science® | | | | | | |
| In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector |
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| Author(s): Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D |
| Source: SCIENCE Volume: 272 Issue: 5259 Pages: 263-267 Published: APR 12 1996 |
| Times Cited: 2,118 References: 66 |
| Abstract: A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human primary macrophages. Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy. |
| Document Type: Article |
| Language: English |
Addresses:
1. SALK INST BIOL STUDIES, LA JOLLA, CA 92037 USA
2. WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UE729 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |