| | |  | | | | Record from Web of Science® | | | | | | |
| Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins |
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| Author(s): Fedele M, Bandiera A, Chiappetta G, Battista S, Viglietto G, Manfioletti G, Casamassimi A, Santoro M, Giancotti V, Fusco A |
| Source: CANCER RESEARCH Volume: 56 Issue: 8 Pages: 1896-1901 Published: APR 15 1996 |
| Times Cited: 111 References: 37 |
| Abstract: A correlation has previously been demonstrated between the presence of the three HMGI proteins (HMGI, HMGY, and HMGI-C) and the expression of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells; this being subsequently extended to experimental thyroid, lung, prostate, mammary, and skin carcinomas. Recently, we have demonstrated that expression of HMGI and HMGY proteins, coded for by the HMGI(Y) gene, is associated with the malignant phenotype of human thyroid neoplasias. Here, we show that HMGI(Y) gene expression is present both at the RNA and protein level in human colorectal carcinoma fell lines and tissues examined in this study, Conversely, no HMGI(Y) proteins were detected in normal intestinal mucosa. Therefore, these results suggest an involvement of HMGI and HMGY proteins overexpression in colorectal tumorigenesis. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV REGGIO CALABRIA, FAC MED & CHIRURG CATANZARO, DIPARTIMENTO SPERIMENTALE & CLIN, I-88100 CATANZARO, ITALY
2. FDN SENATORE PASCALE, IST NAZL TUMORI, I-80131 NAPLES, ITALY
3. UNIV TRIESTE, DIPARTIMENTO BIOCHIM BIOFIS & CHIM MACROMOLEC, I-34127 TRIESTE, ITALY
4. UNIV NAPLES FEDERICO II, FAC MED & CHIRURG, DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC, I-80131 NAPLES, ITALY |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: UE735 |
| ISSN: 0008-5472 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |