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| Abnormal behavior and neurotransmissions of tenascin gene knockout mouse |
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| Author(s): Fukamauchi F, Mataga N, Wang YJ, Sato S, Yoshiki A, Kusakabe M |
| Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 221 Issue: 1 Pages: 151-156 Published: APR 5 1996 |
| Times Cited: 61 References: 15 |
| Abstract: To examine the role of tenascin (TN) in vivo, we have produced mice in which the TN gene is inactivated. In behavioral studies, TN-knockout mice showed abnormal behavior such as hyperlocomotion and poor swimming ability. Biochemical analysis revealed that serotonin (5-HT) and dopamine (DA) transmission was decreased in the cerebral cortex, the hippocampus, or the striatum of TN-knockout mouse brain. The intraperitoneal administration of the DA receptor agonist, LY171555 (0.5 mg/kg, BW), inhibited the hyperlocomotion, and swimming behavior was transiently improved by the treatment with the 5-HT receptor agonist, 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride. These findings suggest that TN may play an important role in neurotransmissions related to behavior. (C) 1996 Academic Press, Inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST PHYS & CHEM RES, TSUKUBA LIFE SCI CTR, DIV EXPTL ANIM RES, TSUKUBA, IBARAKI 305 JAPAN
2. TOKYO MED & DENT UNIV, MED RES INST, DEPT MOLEC MED SCI, CHIYODA KU, TOKYO 101, JAPAN |
| Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 |
| Subject Category: Biochemistry & Molecular Biology; Biophysics |
| IDS Number: UF049 |
| ISSN: 0006-291X |
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