| | |  | | | | Record from Web of Science® | | | | | | |
| A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p |
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| Author(s): Taunton J, Hassig CA, Schreiber SL |
| Source: SCIENCE Volume: 272 Issue: 5260 Pages: 408-411 Published: APR 19 1996 |
| Times Cited: 924 References: 20 |
| Abstract: Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription. |
| Document Type: Article |
| Language: English |
Addresses:
1. HARVARD UNIV, HOWARD HUGHES MED INST, DEPT CHEM & BIOL CHEM, CAMBRIDGE, MA 02138 USA
2. HARVARD UNIV, HOWARD HUGHES MED INST, DEPT MOLEC & CELLULAR BIOL, CAMBRIDGE, MA 02138 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UG252 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |