| | |  | | | | Record from Web of Science® | | | | | | |
| Molecular genetics of human blood pressure variation |
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| Author(s): Lifton RP |
| Source: SCIENCE Volume: 272 Issue: 5262 Pages: 676-680 Published: MAY 3 1996 |
| Times Cited: 390 References: 75 |
| Abstract: Hypertension is a common multifactorial vascular disorder of largely unknown cause. Recognition that hypertension is in part genetically determined has motivated studies to identify mutations that confer susceptibility. Thus far, mutations in at least 10 genes have been shown to alter blood pressure; most of these are rare mutations imparting large quantitative effects that either raise or lower blood pressure. These mutations alter blood pressure through a common pathway, changing salt and water reabsorption in the kidney. These findings demonstrate the utility of molecular genetic approaches to the understanding of blood pressure variation and may provide insight into the physiologic mechanisms underlying common forms of hypertension. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lifton, RP (reprint author), YALE UNIV, SCH MED, HOWARD HUGHES MED INST, 295 CONGRESS AVE, NEW HAVEN, CT 06510 USA |
Addresses:
1. YALE UNIV, SCH MED, DEPT MED, BOYER CTR MOLEC MED, NEW HAVEN, CT 06510 USA
2. YALE UNIV, SCH MED, DEPT GENET, NEW HAVEN, CT 06510 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UJ051 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |