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| Water increases the fluidity of intercellular membranes of stratum corneum: Correlation with water permeability, elastic, and electrical resistance properties |
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| Author(s): Alonso A, Meirelles NC, Yushmanov VE, Tabak M |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 106 Issue: 5 Pages: 1058-1063 Published: MAY 1996 |
| Times Cited: 37 References: 31 |
| Abstract: We used the spin label electron spin resonance technique to monitor the hydration effect on the molecular dynamics of lipids at C-5, C-12, and C-16 positions of the allkyl chain. Increase in water content of neonatal rat SC leads to an increase in membrane fluidity, especially in the region near the membrane-water interface. The effect is less pronounced deeper inside the hydrophobic core. The reorientational correlation time at the C-16 position of hydrocarbon chains showed a higher change up to similar to 18% (w/w) of water content. This behavior was accompanied by an exponential decay both in elastic modulus and electrical resistance with water content. On the contrary, the segmental motion at C-5 and C-12 positions of the chain and the permeability constant increased in the range of around 18% (w/w) up to the fully hydrated condition (58 +/- 7%). Our results give a better characterization of the fluidity of SC and show that it is the principal parameter involved in the mechanism of the permeability of different compounds through skin. |
| Document Type: Article |
| Language: English |
| Reprint Address: Alonso, A (reprint author), UNIV CAMPINAS, DEPT ELETRONICA QUANTICA, INST FIS, BR-13083 CAMPINAS, SP BRAZIL |
Addresses:
1. UNIV CAMPINAS, INST BIOL, BR-13083 CAMPINAS, SP BRAZIL
2. UNIV SAO PAULO, INST QUIM, BR-13560 SAO CARLOS, SP BRAZIL |
| Publisher: BLACKWELL SCIENCE INC, 238 MAIN ST, CAMBRIDGE, MA 02142 |
| Subject Category: Dermatology |
| IDS Number: UJ131 |
| ISSN: 0022-202X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |