| | |  | | | | Record from Web of Science® | | | | | | |
| MADR1, a MAD-related protein that functions in BMP2 signaling pathways |
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| Author(s): Hoodless PA, Haerry T, Abdollah S, Stapleton M, OConnor MB, Attisano L, Wrana JL |
| Source: CELL Volume: 85 Issue: 4 Pages: 489-500 Published: MAY 17 1996 |
| Times Cited: 502 References: 57 |
| Abstract: Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and are required for signaling by the TGF beta superfamily have been poorly defined. The Drosophila gene Mothers against dpp (Mad) and the C. elegans sma genes are implicated in these signaling pathways. We show that MAD functions downstream of DPP receptors and is required for receptor signaling. Phosphorylation of MADR1, a human homolog of MAD, is tightly regulated and rapidly induced by BMP2, but not TGF beta or activin. This phosphorylation is necessary for function, since a point mutant that yields a null phenotype in Drosophila is not phosphorylated. BMP2 treatment results in accumulation of MADR1 in the nucleus. MAD proteins may thus define a novel class of signaling molecules with nuclear function in Ser/Thr kinase receptor signaling pathways. |
| Document Type: Article |
| Language: English |
Addresses:
1. HOSP SICK CHILDREN, PROGRAM DEV BIOL, TORONTO, ON M5G 1X8 CANADA
2. HOSP SICK CHILDREN, DIV GASTROENTEROL, TORONTO, ON M5G 1X8 CANADA
3. UNIV CALIF IRVINE, DEPT MOLEC BIOL & BIOCHEM, IRVINE, CA 92717 USA
4. UNIV CALIF IRVINE, CTR DEV BIOL, IRVINE, CA 92717 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: UM415 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |