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| A genome-wide search for human non-insulin dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 |
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| Author(s): Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, GogolinEwens KJ, Shephard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzsch H, Schroder HE, Schulze J, Cox NJ, Menzel S, Boriraj VV, Chen X, Lim LR, Lindner T, Mereu LE, Wang YQ, Xiang K, Yamagata K, Yang Y, Bell GI |
| Source: NATURE GENETICS Volume: 13 Issue: 2 Pages: 161-166 Published: JUN 1996 |
| Times Cited: 424 References: 44 |
| Abstract: Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factor splay an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non- and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hanis, CL (reprint author), UNIV TEXAS, HLTH SCI CTR, CTR HUMAN GENET, POB 20334, HOUSTON, TX 77030 USA |
Addresses:
1. VIRGINIA MASON RES CTR, SEATTLE, WA 98101 USA
2. UNIV WASHINGTON, DEPT IMMUNOL, SEATTLE, WA 98195 USA
3. UNIV PENN, SCH MED, DEPT GENET, PHILADELPHIA, PA 19104 USA
4. STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA
5. TOKYO WOMENS MED COLL, CTR DIABET, TOKYO 162, JAPAN
6. TECH UNIV DRESDEN, UNIV CLIN CARL GUSTAV CARUS, DEPT INTERNAL MED 3, O-8027 DRESDEN, GERMANY
7. UNIV CHICAGO, HOWARD HUGHES MED INST, CHICAGO, IL 60637 USA
8. UNIV CHICAGO, DEPT BIOCHEM & MOLEC BIOL, CHICAGO, IL 60637 USA
9. UNIV CHICAGO, DEPT MED, CHICAGO, IL 60637 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: UN395 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |