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| A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer |
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| Author(s): Borysiewicz LK, Fiander A, Nimako M, Man S, Wilkinson GWG, Westmoreland D, Evans AS, Adams M, Stacey SN, Boursnell MEG, Rutherford E, Hickling JK, Inglis SC |
| Source: LANCET Volume: 347 Issue: 9014 Pages: 1523-1527 Published: JUN 1 1996 |
| Times Cited: 326 References: 26 |
| Abstract: Background Human papillomavirus (HPV) infection, especially with type 16 or 18, is associated with cervical cancer, Two HPV proteins, E6 and E7, are consistently expressed in tumour cells. The objectives of the study were to examine the clinical and environmental immunogenicity in the first clinical recombinant vaccinia virus expressing proteins of HPV 16 and 18 (TA-HPV). Methods The study was an open label phase I/II trial in eight patients with late stage cervical cancer. The patients were vaccinated with a single dose of TA-HPV and kept in strict isolation to monitor local and systemic side-effects, environmental spread, and anti-E6/E7 immune responses.
Findings Vaccination resulted in no significant clinical side-effects and there was no environmental contamination by live TA-HPV. Each patient mounted an antivaccinia antibody response and three of the eight patients developed an HPV-specific antibody response that could be ascribed to the vaccination. HPV-specific cytotoxic T lymphocytes, the effector mechanism most likely to be of therapeutic benefit, were detected in one of three evaluable patients.
Interpretation Further studies to investigate the use of TA-HPV for immunotherapy of cervical cancer are warranted.
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| Document Type: Article |
| Language: English |
| Reprint Address: Borysiewicz, LK (reprint author), UNIV WALES COLL CARDIFF, COLL MED, DEPT MED, HEATH PK, CARDIFF CF4 4XN, S GLAM WALES |
Addresses:
1. UNIV WALES COLL CARDIFF, COLL MED, DEPT MICROBIOL, CARDIFF CF4 4XN, S GLAM WALES
2. UNIV WALES COLL CARDIFF, COLL MED, DEPT ONCOL & GYNAECOL, CARDIFF CF4 4XN, S GLAM WALES
3. CHRISTIE HOSP NATL HLTH SERV TRUST, PATERSON INST CANC RES, MANCHESTER, LANCS ENGLAND
4. CANTAB PHARMACEUT, CAMBRIDGE, ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: UN473 |
| ISSN: 0140-6736 |
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