| | |  | | | | Record from Web of Science® | | | | | | |
| Rat spermatogenesis in mouse testis |
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| Author(s): Clouthier DE, Avarbock MR, Maika SD, Hammer RE, Brinster RL |
| Source: NATURE Volume: 381 Issue: 6581 Pages: 418-421 Published: MAY 30 1996 |
| Times Cited: 186 References: 22 |
| Abstract: RECENTLY, transplantation of mouse donor spermatogonial stem cells from a fertile testis to an infertile recipient mouse testis was described(1,2). The donor tells established spermatogenesis in the seminiferous tubules of the host, and normal spermatozoa were produced. In the most successful transplants, the recipient mice were fertile and sired up to 80 per cent of progeny from donor cells(2). Here we examine the feasibility of transplanting spermatogonial stem cells from other species to the mouse seminiferous tubule to generate spermatogenesis. Marked testis cells from transgenic rats sere transplanted to the testes of immunodeficient mice, and in all of 10 recipient mice (in 19 of 20 testes), rat spermatogenesis occurred. Epididymides of eight mice were examined, and the three from mice with the longest transplants (greater than or equal to 110 days) contained rat spermatozoa with normal morphology. The generation of rat spermatogenesis in mouse testes suggests that spermatogonial stem cells of many species could be transplanted, and opens the possibility of xenogeneic spermatogenesis for other species. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV PENN, SCH VET MED, REPROD PHYSIOL LAB, PHILADELPHIA, PA 19104 USA
2. UNIV TEXAS, SW MED CTR, HOWARD HUGHES MED INST, DEPT BIOCHEM, DALLAS, TX 75235 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UN479 |
| ISSN: 0028-0836 |
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