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| Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia |
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| Author(s): Du C, Hu R, Csernansky CA, Liu XZ, Hsu CY, Choi DW |
| Source: BRAIN RESEARCH Volume: 718 Issue: 1-2 Pages: 233-236 Published: APR 29 1996 |
| Times Cited: 55 References: 38 |
| Abstract: Previous studies have implicated both excitotoxicity and apoptosis in the pathogenesis of cerebral infarction induced by focal ischemic insults. Here we tested the possibility that the NMDA antagonist, dextrorphan, and the protein synthesis inhibitor, cycloheximide, would produce additive protective effects in a rodent model of focal ischemia-reperfusion. Transient focal cerebral ischemia was induced by a 90 min period of ligation of the right middle cerebral artery and both common carotid arteries. Administration of either 30 mg/kg dextrorphan or 0.5 mg/kg cycloheximide, given i.p. 15 min before ischemia, reduced infarct volume by about 65%. When optimal concentrations of each drug were given together, infarct volume was reduced by 87% as measured 14 days later. These observations support the idea that both excitotoxicity, and apoptosis dependent on new protein synthesis, contribute to cerebral infarction after transient focal ischemia in the rat. |
| Document Type: Article |
| Language: English |
Addresses:
1. WASHINGTON UNIV, SCH MED, DEPT NEUROL, ST LOUIS, MO 63110 USA
2. WASHINGTON UNIV, SCH MED, CTR STUDY NERVOUS SYST INJURY, ST LOUIS, MO 63110 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Neurosciences |
| IDS Number: UP226 |
| ISSN: 0006-8993 |
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