| Molecular cloning of human hyaluronan synthase |
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| Author(s): Itano N, Kimata K |
| Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 222 Issue: 3 Pages: 816-820 Published: MAY 24 1996 |
| Times Cited: 71 References: 12 |
| Abstract: We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated region. Comparative analysis of the predicted coding region with the murine hyaluronan synthase sequence indicates 84.4% and 96.0% identity in nucleotide sequence and amino acid sequences, respectively. Northern analysis indicated that the gene was ubiquitously expressed in various human tissues. (C) 1996 Academic Press, Inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. AICHI MED UNIV, INST MOLEC SCI MED, NAGAKUTE, AICHI 48011 JAPAN |
| Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 |
| Subject Category: Biochemistry & Molecular Biology; Biophysics |
| IDS Number: UP427 |
| ISSN: 0006-291X |