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| Identification of a major co-receptor for primary isolates of HIV-1 |
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| Author(s): Deng HK, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, DiMarzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Landau NR |
| Source: NATURE Volume: 381 Issue: 6584 Pages: 661-666 Published: JUN 20 1996 |
| Times Cited: 2,303 References: 44 |
| Abstract: Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1 alpha and MIP-1 beta. |
| Document Type: Article |
| Language: English |
Addresses:
1. NYU, MED CTR, SKIRBALL INST BIOMOL MED, NEW YORK, NY 10016 USA
2. NYU, MED CTR, HOWARD HUGHES MED INST, NEW YORK, NY 10016 USA
3. ROCKEFELLER UNIV, AARON DIAMOND AIDS RES CTR, NEW YORK, NY 10016 USA
4. STANFORD UNIV, MED CTR, DEPT BIOCHEM, STANFORD, CA 94305 USA
5. UNIV LOUISVILLE, SCH MED, JAMES GRAHAM BROWN CANC CTR, LOUISVILLE, KY 40207 USA
6. DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT IMMUNOL, PALO ALTO, CA 94304 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UR979 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |