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| The prognostic value of NCAM, p53 and cyclin D1 in resected non-small cell lung cancer |
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| Author(s): Kwa HB, Michalides RJAM, Dijkman JH, Mooi WJ |
| Source: LUNG CANCER Volume: 14 Issue: 2-3 Pages: 207-217 Published: JUN 1996 |
| Times Cited: 27 References: 42 |
| Abstract: Expression of the neural cell adhesion molecule, NCAM, in frozen sections has been associated with decreased postoperative survival in non-small cell lung carcinoma. Of the various isoforms of NCAM described, the highly sialylated isoform plays a role in the migration of embryonal cells from the neural crest and is expressed by highly malignant tumours such as small cell lung carcinomas. We investigated the clinical significance of expression of this NCAM isoform as a prognostic factor in a series of 96 non-small cell lung carcinomas resected with curative intent. We also evaluated the effect of microwave pretreatment of formalin-fixed, paraffin-embedded sections on the NCAM immunostaining and related the outcome to the postoperative clinical course of disease. In addition, in an attempt to extend our search for possible molecular markers of unfavourable prognosis in lung cancer, we evaluated increased immunostaining for p53 and cyclin D1 in the same series. We did nor find a significant relation between expression of NCAM or its highly sialylated isoform and the length of postoperative survival, The numbers of positive cases (9 and 14, respectively) were relatively low. Increased p53 and cyclin D1 immunostaining (50 and 55 of the 96 tumours) failed io show a significant relation with postoperative survival. In our material, tumour stage was the only significant prognostic factor. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV LEIDEN HOSP, DEPT PULMONOL, 2300 RC LEIDEN, NETHERLANDS
2. NETHERLANDS CANC INST, DIV TUMOR BIOL H5, 1066 CX AMSTERDAM, NETHERLANDS |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Oncology; Respiratory System |
| IDS Number: UR985 |
| ISSN: 0169-5002 |
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