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| Adipose tissue leptin production and plasma leptin kinetics in humans |
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| Author(s): Klein S, Coppack SW, MohamedAli V, Landt M |
| Source: DIABETES Volume: 45 Issue: 7 Pages: 984-987 Published: JUL 1996 |
| Times Cited: 262 References: 23 |
| Abstract: Abdominal adipose tissue leptin production was determined in vivo by arteriovenous balance in 14 lean and obese men (mean BMI 27.0 +/- 1.9, range 21.4-45.2). Blood samples were taken simultaneously from an abdominal vein that drains subcutaneous adipose tissue and from a radial artery, Adipose tissue blood flow was measured by xenon washout, Abdominal vein leptin concentrations (mean 8.9 +/- 2.4 ng/ml, range 2.1-36.5 ng/ml) were consistently greater than arterial values (mean 6.6 +/- 1.9 ng/ml, range 1.7-28.2 ng/ml) (P < 0.001), The net rate of abdominal adipose tissue leptin production (mean 3.2 +/- 0.5 ng . 100 g(-1) . min(-1)) correlated directly with percentage body fat (r(s) = 0.59, P = 0.016), Estimated whole-body leptin production rate (797 +/- 283 ng . person(-1) . min(-1)) correlated directly with percent body fat (r(s) = 0.93, P < 0.0001) and with regional leptin production (r(s) = 0.81, P < 0.001), In contrast, the rate of leptin clearance from plasma (mean 1.50 +/- 0.23 ml . kg(-1) . min(-1)) and plasma leptin half-life (mean 24.9 +/- 4.4 min) was unrelated to adiposity (r(s) = 0.06, P = 0.30; r(s) = 0.16, P = 0.30, respectively), These results provide direct evidence that leptin is produced by adipose tissue in humans and that the rate of production is directly related to adiposity, A combination of greater leptin production per unit of body fat and increased production from expanded total body fat mass, rather than alterations in leptin clearance, account for the increase in plasma leptin concentrations observed in obese humans. |
| Document Type: Article |
| Language: English |
| Reprint Address: Klein, S (reprint author), WASHINGTON UNIV, SCH MED, DEPT INTERNAL MED, 660 S EUCLID AVE, BOX 8127, ST LOUIS, MO 63110 USA |
Addresses:
1. WASHINGTON UNIV, SCH MED, DEPT PEDIAT, ST LOUIS, MO 63110 USA
2. UCL, SCH MED, DEPT MED, LONDON W1N 8AA, ENGLAND |
| Publisher: AMER DIABETES ASSOC, 1660 DUKE ST, ALEXANDRIA, VA 22314 |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: UU168 |
| ISSN: 0012-1797 |
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