| | |  | | | | Record from Web of Science® | | | | | | |
| Induction of bystander T cell proliferation by viruses and type I interferon in vivo |
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| Author(s): Tough DF, Borrow P, Sprent J |
| Source: SCIENCE Volume: 272 Issue: 5270 Pages: 1947-1950 Published: JUN 28 1996 |
| Times Cited: 659 References: 32 |
| Abstract: T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal response directed to various environmental antigens, However, the massive proliferation of T cells seen in viral infections is suggestive of a bystander reaction driven by cytokines instead of the TCR. In mice, T cell proliferation in viral infections preferentially affected the CD44(hi) subset of CD8(+) cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I interferon (IFN I), and also by purified IFN I; such proliferation was not associated with up-regulation of CD69 or CD25 expression, which implies that TCR signaling was not involved, IFN I [poly(I:C)]-stimulated CD8(+) cells survived for prolonged periods in vivo and displayed the same phenotype as did long-lived antigen-specific CD8(+) cells, IFN I also potentiated the clonal expansion and survival of CD8(+) cells responding to specific antigen, Production of IFN I may thus play an important role in the generation and maintenance of specific memory. |
| Document Type: Article |
| Language: English |
Addresses:
1. Scripps Res Inst, DEPT IMMUNOL, IMM4, LA JOLLA, CA 92037 USA
2. Scripps Res Inst, DEPT NEUROPHARMACOL, IMM6, LA JOLLA, CA 92037 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UV294 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |