| | |  | | | | Record from Web of Science® | | | | | | |
| CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 |
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| Author(s): Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA |
| Source: SCIENCE Volume: 272 Issue: 5270 Pages: 1955-1958 Published: JUN 28 1996 |
| Times Cited: 1,840 References: 32 |
| Abstract: Human immunodeficiency virus-type 1 (HIV-1) entry requires fusion cofactors on the CD4(+) target cell. Fusin, a heterotrimeric GTP-binding protein (G protein)-coupled receptor, serves as a cofactor for T cell line-tropic isolates. The chemokines RANTES, MIP-1 alpha, and MIP-1 beta, which suppress infection by macrophage-tropic isolates, selectively inhibited cell fusion mediated by the corresponding envelope glycoproteins (Envs). Recombinant CC CKR5, a G protein-coupled receptor for these chemokines, rendered CD4-expressing nonhuman cells fusion-competent preferentially with macrophage-tropic Envs. CC CKR5 messenger RNA was detected selectively in cell types susceptible to macrophage-tropic isolates. CC CKR5 is thus a fusion cofactor for macrophage-tropic HIV-1 strains. |
| Document Type: Article |
| Language: English |
Addresses:
1. NIAID, HOST DEF LAB, NIH, BETHESDA, MD 20892 USA
2. NIAID, VIRAL DIS LAB, NIH, BETHESDA, MD 20892 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UV294 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |