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| Renal agenesis and the absence of enteric neurons in mice lacking GDNF |
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| Author(s): Sanchez MP, SilosSantiago I, Frisen J, He B, Lira SA, Barbacid M |
| Source: NATURE Volume: 382 Issue: 6586 Pages: 70-73 Published: JUL 4 1996 |
| Times Cited: 717 References: 26 |
| Abstract: GLIAL-CELL-LINE-DERIVED neurotrophic factor (GDNF)(1) is a potent survival factor for dopaminergic neurons and motor neurons in culture(1,2). It also protects these neurons from degeneration in vitro(3-9), and improves symptoms like Parkinson's disease induced pharmacologically in rodents(10) and monkeys(11), Thus GDNF might have beneficial effects in the treatment of Parkinson's disease and amyotrophic lateral sclerosis, To examine the physiological role of GDNF in the development of the mammalian nervous system, we have generated mice defective in GDNF expression by using homologous recombination in embryonic stem cells to delete each of its two coding exons(1), GDNF-null mice, regardless of their targeted mutation, display complete renal agenesis owing to lack of induction of the ureteric bud, an early step in kidney development, These mice also have no enteric neurons, which probably explains the observed pyloric stenosis and dilation of their duodenum, However, ablation of the GDNF gene does not affect the differentiation and survival of dopaminergic neurons, at least during embryonic development. |
| Document Type: Article |
| Language: English |
Addresses:
1. BRISTOL MYERS SQUIBB PHARMACEUT RES INST, DEPT MOLEC ONCOL, PRINCETON, NJ 08543 USA
2. BRISTOL MYERS SQUIBB PHARMACEUT RES INST, TRANSGEN UNIT, PRINCETON, NJ 08543 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: UV473 |
| ISSN: 0028-0836 |
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