| | |  | | | | Record from Web of Science® | | | | | | |
| Mismatch repair in replication fidelity, genetic recombination, and cancer biology |
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| Author(s): Modrich P, Lahue R |
| Source: ANNUAL REVIEW OF BIOCHEMISTRY Volume: 65 Pages: 101-133 Published: 1996 |
| Times Cited: 981 References: 225 |
| Abstract: Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by blocking recombination events between divergent DNA sequences. The reaction responsible for strand-specific correction of mispaired bases has been highly conserved during evolution, and homologs of bacterial MutS and MutL, which play key roles in mismatch recognition and initiation of repair, have been identified in yeast and mammalian cells. Inactivation of genes encoding these activities results in a large increase in spontaneous mutability, and in the case of mice and men, predisposition to tumor development. |
| Document Type: Review |
| Language: English |
| Reprint Address: Modrich, P (reprint author), DUKE UNIV, MED CTR, HOWARD HUGHES MED INST, DURHAM, NC 27710 USA |
Addresses:
1. DUKE UNIV, MED CTR, DEPT BIOCHEM, DURHAM, NC 27710 USA
2. UNIV MASSACHUSETTS, MED CTR, DEPT BIOCHEM & MOLEC BIOL, WORCESTER, MA 01655 USA |
| Publisher: ANNUAL REVIEWS INC, 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: UV922 |
| ISSN: 0066-4154 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |