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| Marrow engraftment and clinical manifestations of capillary leak syndrome |
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| Author(s): Cahill RA, Spitzer TR, Mazumder A |
| Source: BONE MARROW TRANSPLANTATION Volume: 18 Issue: 1 Pages: 177-184 Published: JUL 1996 |
| Times Cited: 62 References: 65 |
| Abstract: A capillary leak syndrome occurs frequently in bone marrow transplant patients in addition to graft-versus-host-disease and infection, The underlying pathology is poorly understood but the clinical manifestations of excessive weight gain, ascites, and edema associated with kidney and liver abnormalities suggest a common injury to multiple organs, The clinical courses of 55 allogeneic and autologous marrow transplant recipients were retrospectively reviewed with regard to the presentation of a capillary leak syndrome (CLS), Twenty-nine patients (53%) developed non-cardiogenic pulmonary edema with or without concurrent pleural effusions; the incidence was comparable in allogeneic and autologous recipients, Pulmonary features were accompanied by hepatic dysfunction in 28, renal dysfunction in 22, and central nervous system abnormalities in 17, There was a strong correlation between time of engraftment and the first manifestations of CLS, both of which occurred earlier in allogeneic than in autologous transplant recipients, These data confirm that CLS occurs in both allogeneic and autologous transplant recipients and suggest a pivotal contribution by circulating leukocytes. |
| Document Type: Article |
| Language: English |
| Reprint Address: Cahill, RA (reprint author), GEORGETOWN UNIV, VINCENT T LOMBARDI CANC RES CTR, BONE MARROW TRANSPLANTAT PROGRAM, DEPT MED, WASHINGTON, DC 20007 USA |
Addresses:
1. GEORGETOWN UNIV, VINCENT T LOMBARDI CANC RES CTR, BONE MARROW TRANSPLANTAT PROGRAM, DEPT PEDIAT, WASHINGTON, DC 20007 USA
2. NATL NAVAL MED CTR, NAVAL MED RES INST, BETHESDA, MD USA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: VA240 |
| ISSN: 0268-3369 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |