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| Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population |
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| Author(s): Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, Hopkin J |
| Source: HUMAN MOLECULAR GENETICS Volume: 5 Issue: 8 Pages: 1129-1130 Published: AUG 1996 |
| Times Cited: 68 References: 11 |
| Abstract: A genetic association study was performed with coding variants of Fc epsilon RI beta in relation to atopic and non-atopic asthma in a Japanese population (n = 400). A coding variant of Gly237Glu in exon 7 of Fc epsilon RI beta gene showed association with atopic asthma (OR = 3.00, chi(2) = 5.10, p <0.03), but not with non-atopic asthma; this was seen particularly in childhood asthma (OR = 3.92, chi(2) = 8.66, P <0.005). This variant is also associated with very high total serum IgE levels (>mean + 3 SD, OR = 8.56, chi(2) = 46.2, p <0.0001), but not any allergen specific IgE. However, Leu181Ile, another variant of Fc epsilon RI beta related to atopy in British and Australian populations, was not found in this Japanese population. These results suggest that variants of Fc epsilon RI beta may be an important genetic cause of the atopic asthma. |
| Document Type: Article |
| Language: English |
| Reprint Address: Shirakawa, T (reprint author), CHURCHILL HOSP, OSLER CHEST UNIT, OXFORD OX3 7LJ, ENGLAND |
Addresses:
1. OSAKA UNIV, SCH MED, DEPT HYG & PREVENT MED, SUITA, OSAKA 565 JAPAN
2. OSAKA MED COLL, DEPT PEDIAT, TAKATSUKI, OSAKA 569 JAPAN
3. WAKAYAMA MED CTR, JAPANESE RED CROSS SOC, WAKAYAMA, JAPAN
4. KYOTO PREVENT MED CTR, KYOTO, JAPAN |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Genetics & Heredity |
| IDS Number: VB132 |
| ISSN: 0964-6906 |
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