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| Protection against atherogenesis in mice mediated by human apolipoprotein A-IV |
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| Author(s): Duverger N, Tremp G, Caillaud JM, Emmanuel F, Castro G, Fruchart JC, Steinmetz A, Denefle P |
| Source: SCIENCE Volume: 273 Issue: 5277 Pages: 966-968 Published: AUG 16 1996 |
| Times Cited: 148 References: 28 |
| Abstract: Apolipoproteins ave protein constituents of plasma lipid transport particles. Human apolipoprotein A-IV (apoA-IV) was expressed in the liver of C57BL/6 mice and mice deficient in apoE, both of which are prone to atherosclerosis, to investigate whether apoA-IV protects against this disease. In transgenic C57BL/6 mice on an atherogenic diet, the serum concentration of high density lipoprotein (HDL) cholesterol increased by 35 percent, whereas the concentration of endogenous apoA-I decreased by 29 percent, relative to those in transgenic mice on a normal diet. Expression of human apoA-IV in apoE-deficient mice on a normal diet resulted in an even more severe atherogenic lipoprotein profile, without affecting the concentration of HDL cholesterol, than that in nontransgenic apoE-deficient mice. However, transgenic mice of both backgrounds showed a substantial reduction in the size of atherosclerotic lesions. Thus, apoA-IV appears to protect against atherosclerosis by a mechanism that does not involve an increase in HDL cholesterol concentration. |
| Document Type: Article |
| Language: English |
| Reprint Address: Duverger, N (reprint author), RHONE POULENC RORER, GENCELL DIV, ATHEROSCLEROSIS DEPT, CTR RECH VITRY ALFORTVILLE, F-94403 VITRY SUR SEINE, FRANCE |
Addresses:
1. INST PASTEUR, INSERM 325, F-59019 LILLE, FRANCE
2. UNIV MARBURG, ZENTRUM INNERE MED ENDOKRINOL & STOFFWECHSEL, D-35043 MARBURG, GERMANY |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: VC670 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |