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| Cure of short- and long-term experimental Chagas' disease using D0870 |
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| Author(s): Urbina JA, Payares G, Molina J, Sanoja C, Liendo A, Lazardi K, Piras MM, Piras R, Perez N, Wincker P, Ryley JF |
| Source: SCIENCE Volume: 273 Issue: 5277 Pages: 969-971 Published: AUG 16 1996 |
| Times Cited: 119 References: 28 |
| Abstract: Chagas' disease, a protozoan infection by the kinetoplastid Trypanosoma cruzi, constitutes a major public health problem in Latin America. With the use of mouse models of both short- and long-term forms of the disease, the efficacy of D0870, a bis-triazole derivative, was tested. D0870 was able to prevent death and induced parasitological cure in 70 to 90 percent of animals, in both the short- and long-term disease. In contrast, currently used drugs such as nifurtimox or ketoconazole prolonged survival but did not induce significant curing effects. D0870 may be useful in the treatment of human long-term Chagas' disease, a condition that is currently incurable. |
| Document Type: Article |
| Language: English |
| Reprint Address: Urbina, JA (reprint author), INST VENEZOLANO INVEST CIENT, LAB QUIM BIOL, CTR BIOQUIM & BIOFIS, APARTADO 21827, CARACAS 1020A, VENEZUELA |
Addresses:
1. CENT UNIV VENEZUELA, FAC CIENCIAS, DEPT PARASITOL, INST ZOOL TROP, CARACAS 1040, VENEZUELA
2. CTR MED DOCENTE LA TRINIDAD, UNIDAD INVEST, CARACAS 1080, VENEZUELA
3. UNIV MONTPELLIER, FAC MED, LAB GENOME PARASITES, F-34000 MONTPELLIER, FRANCE |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: VC670 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |