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| CY/TBI-800 as a pretransplant regimen for allogeneic bone marrow transplantation for severe aplastic anemia using HLA-haploidentical family donors |
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| Author(s): Tzeng CH, Chen PM, Fan S, Liu JH, Chiou TJ, Hsieh RK |
| Source: BONE MARROW TRANSPLANTATION Volume: 18 Issue: 2 Pages: 273-277 Published: AUG 1996 |
| Times Cited: 16 References: 30 |
| Abstract: Allogeneic BMT is the treatment of choice for patients with SAA who have an HLA-identical sibling donor, The results, however, have been relatively poor for transplants from partially matched family donors or unrelated donors because of the high incidence of graft rejection and/or GVHD, Six multiply transfused patients received a novel conditioning regimen of CY 200 mg/kg and TBI 800 cGy prior to receiving marrow from their HLA-haploidentical family donors, Three recipient-donor pairs were mismatched for one HLA locus, one for two loci and two for three loci, A combination of MTX and CsA was used for GVHD prophylaxis, Engraftment was noted in all six patients, Acute GVHD occurred in four patients, two each for grade I and II, respectively, One patient, who was ABO-compatible ,vith her donor had delayed onset of pure red cell aplasia (PRCA) which completely recovered 6 months after additional immunotherapy with prednisolone, There were two deaths; both occurred while patients were on treatment for GVHD, One was from systemic fungemia and the other probably from cytomegalovirus interstitial pneumonitis (CMV-IP), Four patients (66.7%) have been alive and disease-free for more than 8.2, 27.3, 38.4 and 47.2 months after BMT, respectively, The results suggest that CY/TBI-800 may be a simple and effective conditioning regimen for SAA patients receiving BMT from family members other than HLA-identical siblings. |
| Document Type: Article |
| Language: English |
| Reprint Address: Tzeng, CH (reprint author), VET GEN HOSP, DEPT MED, TRANSFUS MED SECT, 201 SHIH PAI RD, SEC 2, TAIPEI 112, TAIWAN |
Addresses:
1. VET GEN HOSP, DEPT MED, MED ONCOL SECT, TAIPEI 112, TAIWAN
2. NATL YANG MING UNIV, COLL MED, TAIPEI 112, TAIWAN |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: VD053 |
| ISSN: 0268-3369 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |