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| bcl-w, a novel member of the bcl-2 family, promotes cell survival |
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| Author(s): Gibson L, Holmgreen SP, Huang DCS, Bernand O, Copeland NG, Jenkins NA, Sutherland GR, Baker E, Adams JM, Cory S |
| Source: ONCOGENE Volume: 13 Issue: 4 Pages: 665-675 Published: AUG 15 1996 |
| Times Cited: 177 References: 73 |
| Abstract: The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor a gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bar and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene. |
| Document Type: Article |
| Language: English |
Addresses:
1. ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, MELBOURNE, VIC 3050 AUSTRALIA
2. NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, FREDERICK, MD 21702 USA
3. ADELAIDE CHILDRENS HOSP INC, DEPT CYTOGENET & MOL GENET, ADELAIDE, SA 5006 AUSTRALIA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: VD433 |
| ISSN: 0950-9232 |
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