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| The translocation t(8;l6)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein |
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| Author(s): Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RSK, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE |
| Source: NATURE GENETICS Volume: 14 Issue: 1 Pages: 33-41 Published: SEP 1996 |
| Times Cited: 404 References: 59 |
| Abstract: The recurrent translocation t(8;16)(p11;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At the chromosome 8 breakpoint we identify a novel gene, MOZ, which encodes a 2,004-amino-acid protein characterized by two C4HC3 zinc fingers and a single C2HC zinc finger in conjunction with a putative acetyltransferase signature. In-frame MOZ-CBP fusion transcripts combine the MOZ finger motifs and putative acetyltransferase domain with a largely intact CBP. We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ-CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation. |
| Document Type: Article |
| Language: English |
| Reprint Address: Borrow, J (reprint author), MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA |
Addresses:
1. W GERMAN CANC CTR, D-45122 ESSEN 1, GERMANY
2. ST JUDE CHILDRENS HOSP, MEMPHIS, TN 38101 USA
3. MEM SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA
4. JOHNS HOPKINS ONCOL CTR, BALTIMORE, MD 21287 USA
5. UNIV WASHINGTON, MED CTR, SEATTLE, WA 98195 USA
6. UNIV TORONTO, SUNNYBROOK HLTH SCI CTR, TORONTO, ON M4N 3M5 CANADA
7. IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND
8. BRITISH COLUMBIA CANC AGCY, VANCOUVER, BC V5Z 4E6 CANADA
9. UNIV LUND HOSP, DEPT CLIN GENET, S-22185 LUND, SWEDEN
10. UNIV FERRARA, I-44100 FERRARA, ITALY
11. CTR HUMAN GENET, SHEFFIELD S10 5DN, S YORKSHIRE ENGLAND |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: VF611 |
| ISSN: 1061-4036 |
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