| | |  | | | | Record from Web of Science® | | | | | | |
| Progesterone stimulates GABA uptake in human spermatozoa |
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| Author(s): Aanesen A, Fried G, Andersson E, Gottlieb C |
| Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume: 226 Issue: 1 Pages: 88-93 Published: SEP 4 1996 |
| Times Cited: 6 References: 22 |
| Abstract: Progesterone can initiate the mammalian sperm acrosome reaction in vitro, and studies on the effect of progesterone and several other steroids have demonstrated an increased calcium influx following binding to the sperm membrane. We have previously presented data indicating the presence of a GABA transport protein in human spermatozoa. In this study, we have examined the uptake of radiolabelled GABA into human spermatozoa in the presence of progesterone, other steroids known to elevate intracellular calcium, and steroids known to be ineffective as stimulators of calcium influx. The results demonstrate a twofold increase in GABA uptake following preincubation with progesterone or steroids known to stimulate calcium influx. Steroids with minor effects on calcium influx were less effective as stimulators of GABA uptake. (C) 1996 Academic Press, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: Aanesen, A (reprint author), KAROLINSKA HOSP, DEPT WOMAN & CHILD HLTH, DIV OBSTET & GYNECOL, POB 140, S-17176 STOCKHOLM, SWEDEN |
Addresses:
1. KAROLINSKA HOSP, DEPT WOMAN & CHILD HLTH, NEONATAL & REPROD RES LAB, S-17176 STOCKHOLM, SWEDEN |
| Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 |
| Subject Category: Biochemistry & Molecular Biology; Biophysics |
| IDS Number: VF935 |
| ISSN: 0006-291X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |