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| Recombination and nondisjunction in humans and flies |
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| Author(s): Koehler KE, Hawley RS, Sherman S, Hassold T |
| Source: HUMAN MOLECULAR GENETICS Volume: 5 Special Issue: Sp. Iss. SI Pages: 1495-1504 Published: 1996 |
| Times Cited: 106 References: 52 |
| Abstract: Recent studies of Drosophila and humans indicate that aberrant genetic recombination is an important component of nondisjunction in both species. In both, a proportion of nondisjunction is associated with failure to pair and/or recombine and in both, exchanges which are either too distal or too proximal increase the likelihood of malsegregation. In this review we provide two perspectives on these observations: first, a review of exchange and chromosome segregation in model organisms, focusing on Drosophila, and secondly an overview of nondisjunction in humans. This format allows us to describe the paradigms developed from studies of model organisms and to ask whether these paradigms apply to the human situation. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALIF DAVIS, DEPT GENET, SECT MOL & CELLULAR BIOL, DAVIS, CA 95616 USA
2. EMORY UNIV, SCH MED, DEPT GENET & MOL MED, ATLANTA, GA 30322 USA
3. CASE WESTERN RESERVE UNIV, CTR HUMAN GENET, CLEVELAND, OH 44106 USA
4. CASE WESTERN RESERVE UNIV, DEPT GENET, CLEVELAND, OH 44106 USA
5. UNIV HOSP CLEVELAND, CLEVELAND, OH 44106 USA |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Genetics & Heredity |
| IDS Number: VG263 |
| ISSN: 0964-6906 |
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