| | |  | | | | Record from Web of Science® | | | | | | |
| Compartment switching of WNT-2 expression in human breast tumors |
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| Author(s): Dale TC, WeberHall SJ, Smith K, Huguet EL, Jayatilake H, Gusterson BA, Shuttleworth G, OHare M, Harris AL |
| Source: CANCER RESEARCH Volume: 56 Issue: 19 Pages: 4320-4323 Published: OCT 1 1996 |
| Times Cited: 53 References: 29 |
| Abstract: WNT-2 is a secreted polypeptide with mitogenic effects in murine mammary epithelial cells, but its role in human cancer is unknown, Using RNase protection analysis of primary cell preparations and in situ hybridization analysis, we report that WNT-2 is expressed at low levels in normal human breast fibroblasts but not in epithelial cells. WNT-2 was found to be expressed at high levels in both the epithelium and stroma of 5 of 11 infiltrating carcinomas and 2 of 6 fibroadenomas, The high level of WNT-2 expression in tumor epithelium suggests that tumorigenesis may involve the ectopic expression of WNT-2 and the creation of an autocrine Wnt signaling loop. |
| Document Type: Article |
| Language: English |
| Reprint Address: Dale, TC (reprint author), INST CANC RES, HADDOW LABS, SECT CELL BIOL & EXPT PATHOL, 15 COTSWOLD RD, SUTTON SM2 5NG, SURREY ENGLAND |
Addresses:
1. JOHN RADCLIFFE HOSP, INST MOL MED, IMPERIAL CANC RES FUND, MOL ONCOL LAB, OXFORD OX3 9DU, ENGLAND
2. UCL, SCH MED, DEPT SURG, LONDON W1P 7LD, ENGLAND |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: VK307 |
| ISSN: 0008-5472 |
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