| | |  | | | | Record from Web of Science® | | | | | | |
| Treatment of multiple sclerosis with T-cell receptor peptides: Results of a double-blind pilot trial |
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| Author(s): Vandenbark AA, Chou YK, Whitham R, Mass M, Buenafe A, Liefeld D, Kavanagh D, Cooper S, Hashim GA, Offner H, Bourdette DN |
| Source: NATURE MEDICINE Volume: 2 Issue: 10 Pages: 1109-1115 Published: OCT 1996 |
| Times Cited: 144 References: 50 |
| Abstract: A T-cell receptor (TCR) peptide vaccine from the V beta 5.2 sequence expressed in multiple sclerosis (MS) plaques and on myelin basic protein (MBP)-specific T cells boosted peptide-reactive T cells in patients with progressive MS. Vaccine responders had a reduced MBP response and remained clinically stable without side effects during one year of therapy, whereas nonresponders had an increased MBP response and progressed clinically. Peptide-specific T helper 2 cells directly inhibited MBP-specific T helper 1 cells in vitro through the release of interleukin-10, implicating a bystander suppression mechanism that holds promise for treatment of MS and other autoimmune diseases. |
| Document Type: Article |
| Language: English |
| Reprint Address: Vandenbark, AA (reprint author), VET AFFAIRS MED CTR, 3710 SW VET HOSP RD, PORTLAND, OR 97201 USA |
Addresses:
1. OREGON HLTH SCI UNIV, DEPT NEUROL, PORTLAND, OR 97201 USA
2. OREGON HLTH SCI UNIV, DEPT MOL MICROBIOL & IMMUNOL, PORTLAND, OR 97201 USA
3. COUNCIL TOBACCO RES, NEW YORK, NY 10022 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: VK995 |
| ISSN: 1078-8956 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |