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| Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene |
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| Author(s): Ambartsumian NS, Grigorian MS, Larsen IF, Karlstrom O, Sidenius N, Rygaard J, Georgiev G, Lukanidin E |
| Source: ONCOGENE Volume: 13 Issue: 8 Pages: 1621-1630 Published: OCT 17 1996 |
| Times Cited: 109 References: 38 |
| Abstract: Transgenic mice, carrying the mts1 gene, one of the genes involved in the acquisition of the metastatic phenotype, were generated, The mts1 gene was placed under the control of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter leading to overexpression in the lactating mammary gland of transgenic animals, Animals bearing the transgene appear phenotypically normal, Animals of two transgenic lines (Tg463 and Tg507) were crossed with the GRS/A mice, The GRS/A strain is characterized by high incidence of mammary tumors which rarely metastasize, 40% of the tumor bearing hybrid GRS/A mts1 females mere found to develop secondary tumors in the lungs, The Mts1 protein was detected in the transgene primary tumor cells as well as in the corresponding metastases, Nontransgenic littermates expressed the Mts1 protein only in the stromal cells surrounding the tumor but not in the tumor cells by itself, Taken together these observations indicate that overexpression of the mts1 gene in the mouse mammary carcinoma cells gives rise to more aggressive tumors which are able to metastasize. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ambartsumian, NS (reprint author), DANISH CANC SOC, DEPT MOL CANC BIOL, STRANDBLVD 49, DK-2100 COPENHAGEN O, DENMARK |
Addresses:
1. ARMENIAN ACAD SCI, INST MOL BIOL, YEREVAN 44, ARMENIA
2. UNIV COPENHAGEN, DEPT MOL CELL BIOL, DK-1353 COPENHAGEN K, DENMARK
3. KOMMUNE HOSP COPENHAGEN, BARTHOLIN INST, DK-1399 COPENHAGEN K, DENMARK
4. RUSSIAN ACAD SCI, INST GENE BIOL, MOSCOW, RUSSIA |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| IDS Number: VM887 |
| ISSN: 0950-9232 |
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