| | |  | | | | Record from Web of Science® | | | | | | |
| Matrilysin is associated with progression of colorectal tumor |
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| Author(s): Ishikawa T, Ichikawa Y, Mitsuhashi M, Momiyama N, Chishima T, Tanaka K, Yamaoka H, Miyazakic K, Nagashima Y, Akitaya T, Shimada H |
| Source: CANCER LETTERS Volume: 107 Issue: 1 Pages: 5-10 Published: OCT 1 1996 |
| Times Cited: 56 References: 19 |
| Abstract: Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matrilysin with lower levels than cancers. The level of matrilysin mRNA expression increased with the advancement of stages of colorectal cancers, consequently a relatively higher expression was observed in liver metastatic tumors than primary tumors. These results suggest that matrilysin mRNA expression was correlated with the progression of colorectal tumors, and this enzyme may also play a role in developing metastatic tumors in liver. |
| Document Type: Article |
| Language: English |
| Reprint Address: Ishikawa, T (reprint author), YOKOHAMA CITY UNIV, SCH MED, DEPT SURG, KANAZAWA KU, 3-9 FUKUARA, YOKOHAMA, KANAGAWA 236 JAPAN |
Addresses:
1. YOKOHAMA CITY UNIV, SCH MED, DEPT PATHOL, KANAZAWA KU, YOKOHAMA, KANAGAWA 236 JAPAN
2. HITACHI CHEM RES CTR, IRVINE, CA USA
3. HITACHI CHEM CO, HITACHI, IBARAKI JAPAN
4. YOKOHAMA CITY UNIV, KIHARA INST BIOL RES, YOKOHAMA, KANAGAWA JAPAN |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Oncology |
| IDS Number: VP941 |
| ISSN: 0304-3835 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |