| | |  | | | | Record from Web of Science® | | | | | | |
| Dual roles for patched in sequestering and transducing hedgehog |
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| Author(s): Chen Y, Struhl G |
| Source: CELL Volume: 87 Issue: 3 Pages: 553-563 Published: NOV 1 1996 |
| Times Cited: 444 References: 51 |
| Abstract: Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chen, Y (reprint author), COLUMBIA UNIV COLL PHYS & SURG, HOWARD HUGHES MED INST, DEPT GENET & DEV, NEW YORK, NY 10032 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: VQ466 |
| ISSN: 0092-8674 |
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