| | |  | | | | Record from Web of Science® | | | | | | |
| Mapping of a gene for Parkinson's disease to chromosome 4q21-q23 |
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| Author(s): Polymeropoulos MH, Higgins JJ, Golbe LI, Johnson WG, Ide SE, DiIorio G, Sanges G, Stenroos ES, Pho LT, Schaffer AA, Lazzarini AM, Nussbaum RL, Duvoisin RC |
| Source: SCIENCE Volume: 274 Issue: 5290 Pages: 1197-1199 Published: NOV 15 1996 |
| Times Cited: 349 References: 34 |
| Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD. |
| Document Type: Article |
| Language: English |
| Reprint Address: Polymeropoulos, MH (reprint author), NIH, LAB GENET DIS RES, NATL CTR HUMAN GENOME RES, BETHESDA, MD 20892 USA |
Addresses:
1. NINCDS, CLIN NEUROGENET UNIT, MED NEUROL BRANCH, NIH, BETHESDA, MD 20892 USA
2. UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, PISCATAWAY, NJ 08854 USA
3. UNIV NAPLES 2, FAC MED, IST SCI NEUROL, NAPLES, ITALY |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: VT335 |
| ISSN: 0036-8075 |
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