| | |  | | | | Record from Web of Science® | | | | | | |
| Biochemical evidence that Patched is the Hedgehog receptor |
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| Author(s): Marigo V, Davey RA, Zuo Y, Cunningham JM, Tabin CJ |
| Source: NATURE Volume: 384 Issue: 6605 Pages: 176-179 Published: NOV 14 1996 |
| Times Cited: 473 References: 29 |
| Abstract: THE protein Sonic hedgehog (Shh) is essential for a variety of patterning events during development. It is the signal from the notochord that induces ventral cell fate in the neural tube and somites(1,2), and is the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud(3). Because of these and other inductive functions of Shh, it is important to understand how the Hedgehog (Hh) signal is received by the target cells. Here we describe binding studies using labelled Shh that strongly suggest that the Hh receptor is encoded by patched (ptc), a gene first identified in genetic screens in Drosophila(4). |
| Document Type: Article |
| Language: English |
Addresses:
1. HARVARD UNIV, SCH MED, DEPT GENET, BOSTON, MA 02115 USA
2. BRIGHAM & WOMENS HOSP, HOWARD HUGHES MED INST, BOSTON, MA 02115 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: VT336 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |