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| Quinton-Mahurkar catheter as short-term central venous access for PBSC collection: Single-center experience of 370 aphereses in 110 patients |
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| Author(s): Alegre A, Requena MJ, FernandezVillalta MJ, Orts M, Gilsanz F, Tomas JF, Arranz R, GilFernandez JJ, Granda A, Bernardo MR, Passanisi M, Granados E, FernandezRanada JM |
| Source: BONE MARROW TRANSPLANTATION Volume: 18 Issue: 5 Pages: 865-869 Published: NOV 1996 |
| Times Cited: 13 References: 26 |
| Abstract: We retrospectively analyzed our experience with the Quinton-Mahurkar dual-lumen hemodialysis catheter as short-term central venous access for harvesting peripheral blood stem cells (PBSC) for autologous transplantation, For intensification therapy for various malignancies 370 leukaphereses were performed in 110 candidates. The catheter was placed percutaneously under local anesthesia only for the time of blood collection and in no case was it used for the PBSC transplant, No systemic antithrombotic prophylaxis was administered, PBSC were collected using a continuous flow cell separator, COBE Spectra, after mobilization with chemotherapy followed by cytokine: rhGM-CSF and rhG-CSF s.c. (35 patients) or rhG-CSF s.c. alone (75 patients). The median number of aphereses was two (1-13), Eighty-nine patients (81.3%) required three or fewer sessions to collect the minimum mononuclear cell target number of 6 x 10(8) MNC/kg. The volume of blood per kg body weight processed for each apheresis was 240 ml (range 150-560 ml) equivalent to 13 l (6-30 l) and the median flow rate was 61 ml/min (range 30-90 ml/min), The total CD34(+) cell yield per patient was 3.55 x 10(6)/kg (0.26-34.8) and the MNC yield was 6.1 x 10(8)/kg (2.96-12.6), We observed the following complications: local infection in four cases (3.6%), catheter occlusion for local thrombosis in two cases (1.8%) and pneumothorax in one case (0.97%), In our experience the Mahurkar-Quinton catheter, when placed specifically for apheresis sessions, was very effective and safe for PBSC harvesting with a low incidence of complications. |
| Document Type: Article |
| Language: English |
| Reprint Address: Alegre, A (reprint author), HOSP UNIV PRINCESA, DEPT HAEMATOL, DIEGO DE LEON 62, MADRID 28006, SPAIN |
Addresses:
1. HOSP UNIV PRINCESA, DEPT ANAESTHESIA, MADRID 28006, SPAIN |
| Publisher: STOCKTON PRESS, HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS |
| Subject Category: Biophysics; Oncology; Hematology; Immunology; Transplantation |
| IDS Number: VT498 |
| ISSN: 0268-3369 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |