| | |  | | | | Record from Web of Science® | | | | | | |
| Function and regulation of the beta(3)-adrenoceptor |
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| Author(s): Strosberg AD, PietriRouxel F |
| Source: TRENDS IN PHARMACOLOGICAL SCIENCES Volume: 17 Issue: 10 Pages: 373-381 Published: OCT 1996 |
| Times Cited: 120 References: 64 |
| Abstract: The cloning, sequencing and expression in model systems of the previously unidentified beta(3)-adrenoceptor recently led to an extensive functional characterization. Ligand binding and adenylate cyclase activation studies helped define a specific profile that is quite distinct from that of the beta(1)- and beta(2)-adrenoceptors, but strongly reminiscent of most of the 'atypical' beta-adrenoceptor-mediated responses reported in earlier pharmacological studies. More recently, a naturally occurring variation in the human beta(3)-adrenoceptor has been correlated with hereditary obesity and with increased dynamic capacity to add on weight and develop non-insulin dependent diabetes in Western obese patients. Donny Strosberg and France Pietri-Rouxel describe how results now provide a consistent picture of an important role for the human beta(3)-adrenoceptor in the regulation of lipid metabolism and as an obvious target for drugs to treat some forms of obesity and diabetes. |
| Document Type: Review |
| Language: English |
| Reprint Address: Strosberg, AD (reprint author), INST COCHIN GENET MOL, LAB IMMUNOPHARMACOL MOL, CNRS, UPR 0415, F-75014 PARIS, FRANCE |
Addresses:
1. UNIV PARIS, F-75014 PARIS, FRANCE |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Pharmacology & Pharmacy |
| IDS Number: VU526 |
| ISSN: 0165-6147 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |