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| Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenia families |
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| Author(s): Kendler KS, MacLean CJ, ONeill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub RE |
| Source: AMERICAN JOURNAL OF PSYCHIATRY Volume: 153 Issue: 12 Pages: 1534-1540 Published: DEC 1996 |
| Times Cited: 145 References: 41 |
| Abstract: Objective: This study was an attempt to replicate evidence for a vulnerability locus far schizophrenia and associated disorders in the 8p22-21 region reported by Pulver and colleagues. Method: The linkage sample of the Irish Study of High-Density Schizophrenia Families consists of 265 multiplex families containing 1,408 individuals. Fifteen markers covering 30 centimorgans on chromosome 8p were tested. Three statistical methods were used: two-point and multipoint heterogeneity lad scores and a multipoint non-parametric test. Results: According to two-point heterogeneity ion scores, the strongest evidence for linkage was found for workers D8S1731 (maximum lod score=2.00), D8S1715 (maximum lod score=2.52), and D8S133 (maximum lod score=2.08) by assuming a phenotypic definition of all psychiatric illness and a range of genetic models. According to multipoint heterogeneity lod scares, the strongest evidence for linkage (maximum lod score=2.34), found by using a dominant genetic model and a broad definition of the schizophrenia spectrum, extended over a 10-cM region between markers D8S1715 and D8S1739. Multipoint nonparametric linkage found the strongest evidence (maximum z=2.51) over a broader region when either a diagnosis of core schizophrenia or a narrow definition of the schizophrenia spectrum was used. This putative vulnerability locus was segregating in 10%-25% of the families studied. Conclusions: This study supports the existence of a vulnerability locus for schizophrenia on chromosome 8p. In this sample, this locus appears to influence the risk of illness in only, a modest proportion of families and predisposes to a range of schizophrenia spectrum and possibly nonspectrum disorders. |
| Document Type: Article |
| Language: English |
Addresses:
1. VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT PSYCHIAT, RICHMOND, VA 23298 USA
2. VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, DEPT HUMAN GENET, RICHMOND, VA 23298 USA
3. QUEENS UNIV BELFAST, SCH MED, DEPT PSYCHIAT, BELFAST, ANTRIM NORTH IRELAND
4. HLTH RES BOARD, DUBLIN, IRELAND |
| Publisher: AMER PSYCHIATRIC ASSOCIATION, 1400 K ST NW, WASHINGTON, DC 20005 |
| Subject Category: Psychiatry |
| IDS Number: VV491 |
| ISSN: 0002-953X |
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