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| Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region |
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| Author(s): Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL |
| Source: SCIENCE Volume: 274 Issue: 5292 Pages: 1527-1531 Published: NOV 29 1996 |
| Times Cited: 1,858 References: 73 |
| Abstract: Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression and 5-HT uptake in lymphoblasts. Association studies in two independent samples totaling 505 individuals revealed that the 5-HTT polymorphism accounts for 3 to 4 percent of total variation and 7 to 9 percent of inherited variance in anxiety-related personality traits in individuals as well as sibships. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lesch, KP (reprint author), UNIV WURZBURG, DEPT PSYCHIAT, FUCHSLEINSTR 15, D-97080 WURZBURG, GERMANY |
Addresses:
1. NIMH, CLIN SCI LAB, NIH, BETHESDA, MD 20892 USA
2. NCI, BIOCHEM LAB, NIH, BETHESDA, MD 20892 USA
3. UNIV WURZBURG, INST HUMAN GENET, D-97074 WURZBURG, GERMANY |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: VV775 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |