| | |  | | | | Record from Web of Science® | | | | | | |
| Cancer cell cycles |
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| Author(s): Sherr CJ |
| Source: SCIENCE Volume: 274 Issue: 5293 Pages: 1672-1677 Published: DEC 6 1996 |
| Times Cited: 3,300 References: 195 |
| Abstract: Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a) and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RE) and control exit from the G(1) phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this ''RB pathway,'' although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sherr, CJ (reprint author), ST JUDE CHILDRENS HOSP, HOWARD HUGHES MED INST, DEPT TUMOR CELL BIOL, 332 N LAUDERDALE ST, MEMPHIS, TN 38105 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: VW712 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |