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| Testis-derived Sertoli cells survive and provide localized immunoprotection for xenografts in rat brain |
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| Author(s): Sanberg PR, Borlongan CV, Saporta S, Cameron DF |
| Source: NATURE BIOTECHNOLOGY Volume: 14 Issue: 13 Pages: 1692-1695 Published: DEC 1996 |
| Times Cited: 71 References: 22 |
| Abstract: Transplantation of neural tissue into the mammalian central nervous system has become an alternative treatment for neurodegenerative disorders such as Parkinson's disease. Logistical and ethical problems in the clinical use of human fetal neural grafts as a source of dopamine for Parkinson's disease patients has hastened a search for successful ways to use animal dopaminergic cells for human transplantation. The present study demonstrates that transplanted testis-derived Sertoli cells into adult rat brains survive. Furthermore, when cotransplanted with bovine adrenal chromaffin cells (xenograft), Sertoli cells produce localized immunoprotection, suppress microglial response and allow the bovine cells to survive in the rat brain without continuous systemic immunosuppressive drugs. These novel features support Sertoli cells as a viable graft source for facilitating the use of xenotransplantation for Parkinson's disease and suggest their use as facilitators (i.e., localized immunosuppression) for cell transplantation in general. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sanberg, PR (reprint author), UNIV S FLORIDA, COLL MED, DEPT SURG, DIV NEUROL SURG, MDC BOX 16, 12901 B DOWNS BLVD, TAMPA, FL 33612 USA |
Addresses:
1. UNIV S FLORIDA, COLL MED, DEPT NEUROL, TAMPA, FL 33612 USA
2. UNIV S FLORIDA, COLL MED, DEPT PSYCHIAT, TAMPA, FL 33612 USA
3. UNIV S FLORIDA, COLL MED, DEPT PHARMACOL, TAMPA, FL 33612 USA
4. UNIV S FLORIDA, COLL MED, DEPT ANAT, TAMPA, FL 33612 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Biotechnology & Applied Microbiology |
| IDS Number: VX107 |
| ISSN: 1087-0156 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |