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| RSC, an essential, abundant chromatin-remodeling complex |
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| Author(s): Cairns BR, Lorch Y, Li Y, Zhang MC, Lacomis L, ErdjumentBromage H, Tempst P, Du J, Laurent B, Kornberg RD |
| Source: CELL Volume: 87 Issue: 7 Pages: 1249-1260 Published: DEC 27 1996 |
| Times Cited: 386 References: 55 |
| Abstract: A novel 15-subunit complex with the capacity to remodel the structure of chromatin, termed RSC, has been isolated from S. cerevisiae on the basis of homology to the SWI/SNF complex. At least three RSC subunits are related to SWI/SNF polypeptides: Sth1p, Rsc6p, and Rsc8p are significantly similar to Swi2/Snf2p, Swp73p, and Swi3p, respectively, and were identified by mass spectrometric and sequence analysis of peptide fragments. Like SWI/SNF, RSC exhibits a DNA-dependent ATPase activity stimulated by both free and nucleosomal DNA and a capacity to perturb nucleosome structure. RSC is, however, at least 10-fold more abundant than SWI/SNF complex and is essential for mitotic growth. Contrary to a report for SWI/SNF complex, no association of RSC (nor of SWI/SNF complex) with RNA polymerase II holoenzyme was detected. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, SCH MED, DEPT BIOL STRUCT, STANFORD, CA 94305 USA
2. MEM SLOAN KETTERING CANC CTR, PROGRAM MOL BIOL, NEW YORK, NY 10021 USA
3. SUNY HLTH SCI CTR, DEPT MICROBIOL & IMMUNOL, BROOKLYN, NY 11203 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: WA541 |
| ISSN: 0092-8674 |
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