| | |  | | | | Record from Web of Science® | | | | | | |
| The inverse association between tuberculin responses and atopic disorder |
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| Author(s): Shirakawa T, Enomoto T, Shimazu S, Hopkin JM |
| Source: SCIENCE Volume: 275 Issue: 5296 Pages: 77-79 Published: JAN 3 1997 |
| Times Cited: 875 References: 33 |
| Abstract: Human immune responses are heterogeneous and may involve antagonism between T helper (T-H) lymphocyte subsets and their cytokines. Atopy is characterized by immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust mites and pollen, and it underlies the increasingly prevalent disorder asthma. Among Japanese schoolchildren, there was a strong inverse association between delayed hypersensitivity to Mycobacterium tuberculosis and atopy. Positive tuberculin responses predicted a lower incidence of asthma, lower serum IgE levels, and cytokine profiles biased toward T(H)1 type. Exposure and response to M. tuberculosis may, by modification of immune profiles, inhibit atopic disorder. |
| Document Type: Article |
| Language: English |
Addresses:
1. CHURCHILL HOSP, OSLER CHEST UNIT, LUNG RES LAB, OXFORD OX3 7LJ, ENGLAND
2. WAKAYAMA MED CTR, JAPANESE RED CROSS SOC, DEPT OTOLARYNGOL, WAKAYAMA, JAPAN
3. NATL WAKAYAMA HOSP, DEPT PEDIAT, WAKAYAMA, JAPAN |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: WA903 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |